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The story is about Anand Sehgal (Rajesh Khanna), a cancer (lymphosarcoma of the intestine) patient who believes in living his life to the fullest. He comes to Mumbai to live his last months there and to meet his friend Kulkarni (Ramesh Deo). Contrasting Anand is Bhaskar Banerjee (Amitabh Bachchan), a sober doctor, upset with life and the dark reality of his nation. Bhaskar's tête-à-tête with Anand makes him notice the colours behind all the despair and complexity in one's life and teaches him a lesson. After spreading happiness everywhere around himself and changing the lives of many, Anand, as destined, leaves them all, which inspires Bhaskar to write a book on his life.

The film is a narrative, as Bhaskar writes in his diary about his life before Anand, his first meeting, how his relationship with him changes from a doctor-patient to a friend and then to a friend for whom he can do anything, and how a dying man changes his way of thinking to a great extent.